bio-manufacturing
Crucial Metabolism in Bio-manufacturing
Every established or evolving bioprocess has a unique set of metabolic events that limit yield and productivity. Some are very basic – growth kinetics or suboptimal feeding strategies – but others are hidden in the thousands of biochemical pathways that techniques such as transcriptomics or metabolomics fail to clearly identify because of limited sensitivity or to limited analytical horizons.
Metabolic modelling uses robust cellular compositional analyses and process data (on-line and off-line) to construct metabolic models that reflect the kinetics of product formation and space-time yield to identify the Crucial Metabolism that limits productivity.
While traditional academic models of metabolism are constructed to fit limited data sets from wet chemistry. beòcarta’s approach examines the difficult areas where models fail because of unrecognized metabolism competing with the commercial goal of product accumulation. As Arthur Conan Doyle once wrote: “When you have eliminated the impossible, whatever remains, however improbable, must be the truth.” The Sign of the Four (1890).